2-(1,1-Dimethylethyl)-1(2H)-phthalazinone synthesis
- Product Name:2-(1,1-Dimethylethyl)-1(2H)-phthalazinone
- CAS Number:1167442-54-7
- Molecular formula:C12H14N2O
- Molecular Weight:202.25
Yield:1167442-54-7 97.25%
Reaction Conditions:
at 110; for 0.5 h;Large scale;
Steps:
5 Example 5
890 g (10 mol) of tert-butyl hydrazine,1.95kg (13mol) of o-carboxybenzaldehyde was added to the 5L reaction kettle.Heated to 110 ° C,The reaction was kept under mechanical stirring for 30 minutes.TLC or gas phase monitoring reaction, after the reaction is over,1 L of methanol and 0.5 L of isopropanol were added to the reaction system, stirred for 0.6 hours, allowed to stand, and extracted to obtain 1.98 kg of an orange oily liquid.That is, the target compound 5 had a yield of 97.25%.
References:
CN108264488,2018,A Location in patent:Paragraph 0063; 0064
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