2-(1-Bromoethyl)-2-ethyl-1,3-dioxolane synthesis
- Product Name:2-(1-Bromoethyl)-2-ethyl-1,3-dioxolane
- CAS Number:22515-81-7
- Molecular formula:C7H13BrO2
- Molecular Weight:209.08
584-02-1
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$19.00/25g
107-21-1
1370 suppliers
$10.00/25g
22515-81-7
19 suppliers
$320.00/1g
Yield:22515-81-7 92%
Reaction Conditions:
with N-Bromosuccinimide at 20; for 24 h;Reagent/catalyst;
Steps:
3. General procedure for preparation of α-bromoacetal of acetophenones from secondary alcohols
General procedure: A mixture of 2 mmol of substrate, and 4 mL ethylene glycol was stirred for 5 min, and then 2.4 mmol of DBDMH or 4.6 mmol of NBS was added by 5 times in one hour, and the mixture was stirred 24 h at room temperature. Afterward, the mixture was extracted with ether (10 mL × 3). The combined organic layer was washed twice by water (20 mL), and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure, and the residual was treated with alumina chromatography (Petroleum ether/AcOEt=20/1,V/V) to generate the product.
References:
Han, Bingbing;Zheng, Zubiao;Wu, Fang;Wang, Aidong [Synthetic Communications,2017,vol. 47,# 24,p. 2387 - 2394] Location in patent:supporting information
107-21-1
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$10.00/25g
96-22-0
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$9.00/1g
22515-81-7
19 suppliers
$320.00/1g
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22515-81-7
19 suppliers
$320.00/1g
96-22-0
299 suppliers
$9.00/1g
22515-81-7
19 suppliers
$320.00/1g