2-(2,2'-bithiophen-5-ylmethylene)malononitrile synthesis
- Product Name:2-(2,2'-bithiophen-5-ylmethylene)malononitrile
- CAS Number:153308-35-1
- Molecular formula:C12H6N2S2
- Molecular Weight:242.32
3779-27-9
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Yield:153308-35-1 85%
Reaction Conditions:
with N-(3-trifluoromethylphenylcarbamoyl)chitosan in dimethyl sulfoxide at 20; for 72 h;Catalytic behavior;Knoevenagel Condensation;
Steps:
7 2.8. General procedure for Knoevenagel condensation
General procedure: To a solution of the aryl aldehyde (1 equiv.) in DMSO (1.5 mL), malononitrile (or ethyl cyanoacetate) (1.1 equiv.) and chitosan beads or ureydil chitosan derivative 1 disks (10-15 units) were added. The heterogeneous mixture was allowed to stand at room temperature until the reaction was completed monitoring by TLC(1:2 or 1:4 EtOAc-hexane). Then, the reaction was diluted with CH2Cl2(3 mL) and the chitosan beads, or compound 1 disks, fil-tered off. The resulting solution was concentrated, treated with H2O(2.5 mL) and extracted with EtOAc (4 × 10 mL). The organic layers were successively washed with H2O (3 × 15 mL) and brine, then dried (Na2SO4) and concentrated to give the desired product.
References:
Franconetti;Domínguez-Rodríguez;Lara-García;Prado-Gotor;Cabrera-Escribano [Applied Catalysis A: General,2016,vol. 517,p. 176 - 186]
![2-[(5-bromo-thiophen-2-yl)methylene]malononitrile](/CAS/20180629/GIF/81020-78-2.gif)
81020-78-2
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153308-35-1
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4701-17-1
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