2,2,2-TRIFLUORO-N-PIPERIDIN-4-YL-ACETAMIDE synthesis
- Product Name:2,2,2-TRIFLUORO-N-PIPERIDIN-4-YL-ACETAMIDE
- CAS Number:97181-51-6
- Molecular formula:C7H11F3N2O
- Molecular Weight:196.17
97181-50-5
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97181-51-6
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Yield:97181-51-6 70%
Reaction Conditions:
palladium on charcoal in methanol;
Steps:
10 4-trifluoromethylcarbonylamino piperidine (IX)
EXAMPLE 10 4-trifluoromethylcarbonylamino piperidine (IX) A suspension of 92 g of 1-benzyl 4-trifluoromethylcarbonylamino piperidine (X) and 9 g of wet 10% palladium on charcoal in 1000 ml of methanol is left under agitation for 8 days in a hydrogen atmosphere at room temperature. Then it is filtered, the filtrate is evaporated and the residue chromatographed on a silica column (M.P.L.C.). By eluding with pure methanol, 44 g of the expected product are obtained. Melting point: 111° C. Yield: 70% Empirical formula: C7 H11 F3 N2 O
References:
US4808582,1989,A
50541-93-0
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$6.00/5g
97181-51-6
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