ChemicalBook CAS DataBase List 4-Amino-1-benzylpiperidine

4-Amino-1-benzylpiperidine synthesis

12synthesis methods

Product Name:4-Amino-1-benzylpiperidine
CAS Number:50541-93-0
Molecular formula:C12H18N2
Molecular Weight:190.28

949-69-9
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$28.60/10MG

50541-93-0
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$6.00/5g

Yield:50541-93-0 90%

Reaction Conditions:

with sodium in pentan-1-ol; for 2.5 h;Reflux;

Steps:

1 Synthesis of Compound 1c

Compound 1b (2.04 g, 10 mmmol) was dissolved in 50 mL of anhydrous n-amyl alcohol and stirred at reflux, to which was added sodium (2.76 g, 120 mmol) in batches. The reaction was maintained for 2.5 hours. Then the reaction mixture was cooled, adjusted with 1M hydrochloric acid to PH 12 and extracted with water. The combined aqueous phase was adjusted with 1M sodium hydroxide to PH 8. Then the mixture was extracted by ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to give colourless liquid 1c (1.71 g, yield 90%), MS: 191.0 [M+H]+.

References:

US2017/44187,2017,A1 Location in patent:Paragraph 0086; 0088