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ChemicalBook CAS DataBase List 2,2,4,6,7-Pentamethyldihydrobenzofuran
142874-81-5

2,2,4,6,7-Pentamethyldihydrobenzofuran synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C
2: N,N-diethylaniline / 11 h / 220 - 230 °C / Inert atmosphere
3: toluene-4-sulfonic acid / toluene; water / 1.5 h / Reflux

References:

Wakabayashi, Takeshi;Tokunaga, Norihito;Tokumaru, Kazuyuki;Ohra, Taiichi;Koyama, Nobuyuki;Hayashi, Satoru;Yamada, Ryuji;Shirasaki, Mikio;Inui, Yoshitaka;Tsukamoto, Tetsuya [Journal of Medicinal Chemistry,2016,vol. 59,# 10,p. 5109 - 5114]

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