2,2-Bis(4-Hydroxyphenyl)AdaMantane synthesis

Yield:52211-74-2 71%

Reaction Conditions:

Stage #1: 2-Adamantanone;phenol at 50; for 0.5 h;
Stage #2: with methanesulfonic acid;3-mercaptopropionic acid at 50; for 4 h;

Steps:

1 Example 1 Synthesis of 2,2-bis (4-hydroxyphenyl) adamantane

2-adamantanone (75.1 g, 0.50 mol)Phenol (235.3 g, 2.50 mol) was added toThe mixture was stirred at 50 ° C. for 30 minutes to dissolve. Then, 3-mercaptopropionic acid (5.0 g, 47.1 mmol) was added, and methanesulfonic acid was added.(75.0 g, 0.78 mol) at 50 ° C.The mixture was added dropwise over 30 minutes using a dropping funnel and stirred for 4 hours.Thereafter, the mixture was allowed to cool to room temperature, and the precipitated crystals were collected by filtration to obtain crude crystals.Then, methanol (500 g) was added to the crude crystals,Stirred at 60 ° C. for 1 hour. Then, let it cool down to room temperature,The target is obtained by filtering and drying the crystals.2,2-bis (4-hydroxyphenyl) adamantane 113.1 g(Yield 71%) was obtained.

References:

JP2019/210223,2019,A Location in patent:Paragraph 0192-0193