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ChemicalBook CAS DataBase List 2-(2-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

2-(2-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE synthesis

8synthesis methods
-

Yield:32664-13-4 79%

Reaction Conditions:

Stage #1: 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamidewith thionyl chloride
Stage #2: in diethyl ether at 20; for 6 h;
Stage #3: with sodium hydroxide in water;

References:

Cerchia, Carmen;Nasso, Rosarita;Mori, Matteo;Villa, Stefania;Gelain, Arianna;Capasso, Alessandra;Aliotta, Federica;Simonetti, Martina;Rullo, Rosario;Masullo, Mariorosario;De Vendittis, Emmanuele;Ruocco, Maria Rosaria;Lavecchia, Antonio [Journal of Medicinal Chemistry,2019,vol. 62,# 15,p. 7089 - 7110]