2-(2-Fluorophenyl)-1-benzothiophene synthesis
- Product Name:2-(2-Fluorophenyl)-1-benzothiophene
- CAS Number:936734-95-1
- Molecular formula:C14H9FS
- Molecular Weight:228.28
Yield:936734-95-1 78%
Reaction Conditions:
with palladium;sodium acetate in dimethyl sulfoxide at 120; for 24 h;Catalytic behavior;regioselective reaction;Reagent/catalyst;
Steps:
Condition A
General procedure: The DMSO (3 mL) were added in to the ovendried 25 mL R.B.F containing compound 1a (58.57 mg,0.5 mmol, 1 equiv), followed by addition of NaOAc(45.11 mg, 1.1 equiv), Pd NPs (2.39 mg, 2 mol% Pd content:44.48 w/w), iodobenzene 2a (408.02 mg, 2 mmol, 4 equiv).The reaction mixture was stirred at 120 °C for 24 h, aftercomplete conversion of starting material (indicated by TLC),the reaction was quenched with water and the organic layerwas extracted with EtOAc (25 × 3) the combined organiclayer was dried over anhydrous Na2SO4the solvent wasevaporated by rotary evaporator and crude compound waspurified by column chromatography (eluent: 2% EA/Hexane)to get the compound 2-phenyl-1H-indole (3a, 88.01 mg,92%).
References:
Hegde, Rajeev V.;Ong, Tiow-Gan;Ambre, Ram;Jadhav, Arvind H.;Patil, Siddappa A.;Dateer, Ramesh B. [Catalysis Letters,2021,vol. 151,# 5,p. 1397 - 1405]
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