2-(2-Methoxyethoxy)ethanamine synthesis
- Product Name:2-(2-Methoxyethoxy)ethanamine
- CAS Number:31576-51-9
- Molecular formula:C5H13NO2
- Molecular Weight:119.16
52808-36-3
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Yield:31576-51-9 468.91 g
Reaction Conditions:
with ammonia at 130; under 11251.1 Torr; for 6 h;Autoclave;
Steps:
2.1.1; 2.2.1; 2.3.1 Preparation of 2-(2-methoxyethoxy) ethylamine: n1(1-(2-chloroethoxy)-2-methoxyethane): n(ammonia)=1:5, T= 130, react for 6h
Combine 140g 1-(2-chloroethoxy)-2-methoxyethane (content 99%) and 340.6g Ammonia (content 25%) (molar ratio 1:5) was put into the autoclave for reaction, 130, Under 1.5MPa pressure (pressure generated by self-heating, no additional pressure is needed), After 6 hours of reaction, the content of 1-(2-chloroethoxy)-2-methoxyethane in the reactant was detected to be less than 0.5%. The reaction was terminated to obtain crude 2-(2-methoxyethoxy)ethylamine. To the crude 2-(2-methoxyethoxy) ethylamine is added alkali (it can be sodium hydroxide, Alkaline compounds such as strong potassium oxide) to the solution is strong alkaline, pH greater than 13, Excess ammonia gas is extracted under reduced pressure at room temperature, and ammonia gas is absorbed and reused with water. 468.91 g of 2-(2-methoxyethoxy)ethylamine aqueous solution was obtained.
References:
CN108069836, 2021, B Location in patent:Paragraph 0037; 0050-0054; 0059-0062; 0067-0070
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31576-51-9
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![Carbamic acid, [2-(2-methoxyethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/GIF/684221-36-1.gif)
684221-36-1
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