ChemicalBook CAS DataBase List 2,3,5,6-Tetrafluoropyridine

2,3,5,6-Tetrafluoropyridine synthesis

10synthesis methods

Product Name:2,3,5,6-Tetrafluoropyridine
CAS Number:2875-18-5
Molecular formula:C5HF4N
Molecular Weight:151.06

2402-79-1 Synthesis

2402-79-1
254 suppliers
$5.00/1g

2875-18-5
265 suppliers
$12.00/1g

Yield:2875-18-5 95%

Reaction Conditions:

with potassium fluoride in sulfolane at 120; for 6 h;Green chemistry;Reagent/catalyst;Solvent;

Steps:

5-8 Example 8: Preparation of 2,3,5,6-tetrafluoropyridine:
In a 500 mL closed four-mouth reaction bottle,43.4 g of 2,3,5,6-tetrachloropyridine prepared in Example 1 was added,58.0 g of potassium fluoride and solvent 200 mL of sulfolane,The mixture was stirred and controlled at 120 ° C for 6 hours, the reaction was completed, filtered, and the organic phase was distilled, and the fraction of 108 ° C was collected to obtain 28.7 g of 2,3,5,6-tetrafluoropyridine in a yield of 95.0%.

References:

Zhejiang University Of Technology Shangyu Institute Co., Ltd.;Fang Biao;Xu Meng;Ke Junliang CN109251167, 2019, A Location in patent:Paragraph 0013-0016

FullText

700-16-3 Synthesis