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ChemicalBook CAS DataBase List 2,3,5,6-Tetrafluoropyridine

2,3,5,6-Tetrafluoropyridine synthesis

10synthesis methods
-

Yield:2875-18-5 95%

Reaction Conditions:

with potassium fluoride in sulfolane at 120; for 6 h;Green chemistry;Reagent/catalyst;Solvent;

Steps:

5-8 Example 8: Preparation of 2,3,5,6-tetrafluoropyridine:
In a 500 mL closed four-mouth reaction bottle,43.4 g of 2,3,5,6-tetrachloropyridine prepared in Example 1 was added,58.0 g of potassium fluoride and solvent 200 mL of sulfolane,The mixture was stirred and controlled at 120 ° C for 6 hours, the reaction was completed, filtered, and the organic phase was distilled, and the fraction of 108 ° C was collected to obtain 28.7 g of 2,3,5,6-tetrafluoropyridine in a yield of 95.0%.

References:

Zhejiang University Of Technology Shangyu Institute Co., Ltd.;Fang Biao;Xu Meng;Ke Junliang CN109251167, 2019, A Location in patent:Paragraph 0013-0016

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