2',3'-Isopropylidene Ribavirin synthesis
- Product Name:2',3'-Isopropylidene Ribavirin
- CAS Number:52663-90-8
- Molecular formula:C11H16N4O5
- Molecular Weight:284.27
77-76-9
400 suppliers
$9.00/5ml
36791-04-5
605 suppliers
$5.00/100mg
52663-90-8
11 suppliers
$80.00/10mg
Yield:52663-90-8 99%
Reaction Conditions:
with toluene-4-sulfonic acid in acetone at 60; for 3 h;Concentration;Temperature;
Steps:
1C Synthesis of 1 -(2’,3’-Di-O-isopropylidene-(3-D-ribo- thranosyl)-1 ,2,4-triazole-3-carboxamide 5
Synthesis of 1 -(2’,3’-Di-O-isopropylidene-(3-D-ribo- thranosyl)-1 ,2,4-triazole-3-carboxamide 5 Run 2, a suspension ofribavirin (1.05 g, 4.3 mmol), p-toluenesulfonic acid monohydrate (“p-TsOH”) (138 mg, 0.71 mmol) and 2,2-dimethoxypropane (1.0 mE, 7.99 mmol) in acetone (15 mE) was heated at 60° C. for three hours. The mixture was cooled to room temperature, and then 5% aqueous sodium bicarbonate (1 mE) was added to quench the reaction mixture. The precipitate was removed and the filtrate was collected and concentrated. The residue was purified by flash column chromatography on silica using MeOH/DCM (0-10%) to afford the product (1.21 g, 99% yield) as a white solid.
References:
US9149538,2015,B2 Location in patent:Page/Page column 30; 31; 32
77-76-9
400 suppliers
$9.00/5ml
67-64-1
0 suppliers
$19.10/10ml
36791-04-5
605 suppliers
$5.00/100mg
52663-90-8
11 suppliers
$80.00/10mg
122-51-0
506 suppliers
$10.00/5ml
36791-04-5
605 suppliers
$5.00/100mg
52663-90-8
11 suppliers
$80.00/10mg
67-64-1
0 suppliers
$19.10/10ml
36791-04-5
605 suppliers
$5.00/100mg
52663-90-8
11 suppliers
$80.00/10mg
![1H-1,2,4-Triazole-3-carboxylic acid, 1-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-, ethyl ester](/CAS/20210305/GIF/79437-74-4.gif)
79437-74-4
0 suppliers
inquiry
52663-90-8
11 suppliers
$80.00/10mg