2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL synthesis
- Product Name:2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL
- CAS Number:21168-72-9
- Molecular formula:C8H18N2O
- Molecular Weight:158.24
21168-73-0
32 suppliers
inquiry
21168-72-9
46 suppliers
$42.00/250mg
Yield:21168-72-9 47%
Reaction Conditions:
with dimethylsulfide borane complex in tetrahydrofuran at 0; for 2 h;
Steps:
1.27
To the solution of compound 1-(2-hydroxyethyl)piperidine-4-carbonitrile (300 mg, 2 mmol) in dry THF (5 mL) at 0° C., BH3.SMe2 (220 mg, 2.4 mmol) was added dropwise. The mixture was stirred at 0° C. for 2 hrs. Water was added then K2CO3. The mixture was filtered and concentrated to give compound 2-(4-(aminomethyl)piperidin-1-yl)ethanol (150 mg, 47%). (0520) 1H-NMR (CDCl3/400 MHz): δ 3.61-3.70 (m, 1H), 3.59 (t, J=5.6 Hz, 2H), 2.91 (d, J=11.6 Hz, 2H), 2.57 (d, J=6.4 Hz, 2H), 2.50 (t, J=5.6 Hz, 2H), 1.97-2.10 (m, 2H), 1.63-1.70 (m, 2H), 1.15-1.35 (m, 2H).
References:
US9416132,2016,B2 Location in patent:Page/Page column 143; 144
62124-30-5
11 suppliers
$336.00/1g
21168-72-9
46 suppliers
$42.00/250mg
4395-98-6
222 suppliers
$14.00/1g
21168-72-9
46 suppliers
$42.00/250mg
39546-32-2
347 suppliers
$6.00/5g
21168-72-9
46 suppliers
$42.00/250mg