2-(4-Chloro-3-methoxyphenyl)ethan-1-amine synthesis
- Product Name:2-(4-Chloro-3-methoxyphenyl)ethan-1-amine
- CAS Number:96495-22-6
- Molecular formula:C9H12ClNO
- Molecular Weight:185.65
144181-28-2
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96495-22-6
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Yield:96495-22-6 100%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran;
Steps:
86
l-Chloro-2-methoxy-4-(2-nitrovinyl)benzene (I-86a: 800mg, 3.74mmol) in dry THF (1 OmL) was reacted with LAH (278mg, 7.48mmol) in dry THF (1 OmL) to afford 700mg of the product (100%).1H NMR (CDCI3, 300 MHz): δ 7.28-7.26 (m, 1H), 6.76-6.73 (m, 2H), 3.89 (s, 3H), 2.99-2.94 (m, 2H), 2.75-2.70 (m, 2H).
References:
WO2012/35078,2012,A1 Location in patent:Page/Page column 192
13726-16-4
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96495-22-6
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615-74-7
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$16.00/5g
96495-22-6
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13726-17-5
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$45.00/2.5g
96495-22-6
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85740-98-3
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$9.00/250mg
96495-22-6
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