ChemicalBook CAS DataBase List 2,4-Dichlorobenzyl chloride

2,4-Dichlorobenzyl chloride synthesis

6synthesis methods

Product Name:2,4-Dichlorobenzyl chloride
CAS Number:94-99-5
Molecular formula:C7H5Cl3
Molecular Weight:195.47

1777-82-8
360 suppliers
$6.00/5g

94-99-5
365 suppliers
$5.00/10g

Yield:94-99-5 92%

Reaction Conditions:

with phosphorus trichloride in dichloromethane;N,N-dimethyl-formamide at 60 - 80;Reagent/catalyst;

Steps:

6 Example 6
To a 100 mL round bottom flask was added 2,4-dichlorobenzyl alcohol (17.7 g, 0.1 mol) and dichloromethane (30 mL) andDMF (1 mL), followed by the addition of phosphorus trichloride (4.68 g, 0.034 mol) and slowly warming to reflux (60-80 ° C) Should be 2 ~ 3h, TLC detection shows the disappearance of raw materials, distillation was 2,4-dichlorobenzene 17.99g, yield 92%.

References:

Zhejiang Yongtai Pharmaceutical Co., Ltd.;Jin Yizhong;He Renbao;Zhou Guobin;Xie Jianren CN106117028, 2016, A Location in patent:Paragraph 0053; 0054; 0055; 0056

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95-73-8 Synthesis