2,4-DIFLUOROPHENACYL THIOCYANATE synthesis

Yield:887625-49-2 75%

Reaction Conditions:

in ethanol at 80; for 3 h;

Steps:

5.1.5. 1-Phenyl-2-thiocyanatoethanone (17)

General procedure: A mixture of 2-bromo-1-phenylethanone (10 g, 50.0 mmol), potassium thiocyanate (4.90 g, 50.0 mmol), and EtOH (80 mL) was stirred at 80 C for 3.0 h. After cooling to room temperature, the mixture was diluted with water. The solid was collected by filtration and washed with 50% EtOH/water to give 17 (5.99 g, 68%) as a colorless powder.

References:

Kono, Mitsunori;Matsumoto, Takahiro;Kawamura, Toru;Nishimura, Atsushi;Kiyota, Yoshihiro;Oki, Hideyuki;Miyazaki, Junichi;Igaki, Shigeru;Behnke, Craig A.;Shimojo, Masato;Kori, Masakuni [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 1,p. 28 - 41]