2-(4-Iodo-phenoxy)-ethylaMine synthesis
- Product Name:2-(4-Iodo-phenoxy)-ethylaMine
- CAS Number:151978-97-1
- Molecular formula:C8H10INO
- Molecular Weight:263.08
151978-98-2
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151978-97-1
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Yield: 88%
Reaction Conditions:
with hydrogenchloride in diethyl ether;ethanol at 0 - 20; for 12 h;Concentration;Solvent;
Steps:
14.3.1 Step-3.i: Synthesis of2-(4-iodophenoxy)ethan- i-amine
10364] To a stirred solution of tert-butyl (2-(4-iodophe- noxy)ethyl)carbamate (25 g, 68.6 mmol, Example 3, Step-2) in ethanol (50 mE) was added at 0° C., 2M HC1 in ether (250 mE). The reaction mixture was stirred for 12 h at room temperature. After completion of reaction, reaction mixture was basified with saturated NaHCO3, extracted with 10% MeOR in DCM. Organic layer was concentrated under reduced pressure and the crude material was used in next step without further purification (16 g, 88%).
References:
Eisai R&D Management Co., Ltd.;BOCK, Mark;HAO, Ming-Hong;KORPAL, Manav;NYAVANANDI, Vijay Kumar;PUYANG, Xiaoling;SAMAJDAR, Susanta;SMITH, Peter Gerard;WANG, John;ZHENG, Guo Zhu;ZHU, Ping US2016/347717, 2016, A1 Location in patent:Paragraph 0363; 0364
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1000210-73-0
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151978-97-1
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540-38-5
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151978-97-1
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651330-71-1
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151978-97-1
16 suppliers
$149.00/1g
540-38-5
344 suppliers
$10.00/1g
151978-97-1
16 suppliers
$149.00/1g