2-(4-TERT-BUTYL-PHENYL)-BENZOOXAZOL-5-YLAMINE synthesis

Yield:293738-21-3 94%

Reaction Conditions:

with polyphosphoric acid (PPA) at 180;

Steps:

3 2-(4-tert-butylphenyl)benzo[d]oxazole-5-amine (Derivative No.4)

Synthesis Example 3
2-(4-tert-butylphenyl)benzo[d]oxazole-5-amine (Derivative No.4)
2-(4-tert-butylphenyl)benzo[d]oxazole-5-amine (Derivative No.4) was synthesized according to Reaction Scheme 3 below:
8 mmol of 2,4-diaminophenol.2HCl and 8 mmol of 4-tert-butyl-benzoic acid were dissolved in 10 g of PPA, and then, the mixed solution was stirred at a temperature of 180° C. for 3 to 4 hours.
After completion of the reaction, the reaction solution was cooled, neutralized with 10% NaOH, and filtered by using distilled water for recrystallization in a slow manner, thereby obtaining 2.0 g of 2-(4-tert-butylphenyl)benzo[d]oxazole-5-amine (Derivate No.4) (yield: 94%).
1H NMR (400 MHz, Chloroform-d) δ 7.71-7.63 (m, 1H), 7.62-7.54 (m, 1H), 7.27-7.16 (m, 1H), 4.08 (s, 1H), 1.28 (s, 5H).

References:

US2015/197498,2015,A1 Location in patent:Paragraph 0076; 0077; 0078