ChemicalBook CAS DataBase List 2-P-TOLYL-BENZOOXAZOL-5-YLAMINE

2-P-TOLYL-BENZOOXAZOL-5-YLAMINE synthesis

5synthesis methods

Product Name:2-P-TOLYL-BENZOOXAZOL-5-YLAMINE
CAS Number:54995-50-5
Molecular formula:C14H12N2O
Molecular Weight:224.26

137-09-7
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$32.47/25G

99-94-5 Synthesis

99-94-5
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54995-50-5
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$380.00/25g

Yield:54995-50-5 92%

Reaction Conditions:

with polyphosphoric acid at 170; for 1.5 h;

Steps:

General procedure for the preparation of 2-(4-substitutedphenyl/benzyl)-5-aminobenzoxazoles(3a-3l)

General procedure: The derivatives were synthesized by heating 2,4-diaminophenoldihydrochloride (1) (0.01 mol) with suitable acid (2a-2l) (0.01 mol) in polyphosphoric acid (PPA) (24 g) and stirring at170-200 °Cfor 1.5-2.5 h.At the end of the reaction period, theresidue was poured into an ice-water mixture and neutralizedwith an excess of NaOH (10 %) solution, and the residue wasfiltered and boiled with charcoal (200 mg) in ethanol and filtered.After the evaporation of solvent in vacuo, the crudeproduct was obtained and recrystallized from ethanol-water(1:3) mixture (Yildiz-Oren et al., 2004a; Sener et al., 1987;Wynne et al., 2009).

References:

Ertan-Bolelli, Tugba;Yildiz, Ilkay;Ozgen-Ozgacar, Selda [Medicinal Chemistry Research,2016,vol. 25,# 4,p. 553 - 567]