2-P-TOLYL-BENZOOXAZOL-5-YLAMINE synthesis
- Product Name:2-P-TOLYL-BENZOOXAZOL-5-YLAMINE
- CAS Number:54995-50-5
- Molecular formula:C14H12N2O
- Molecular Weight:224.26
137-09-7
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99-94-5
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54995-50-5
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Yield:54995-50-5 92%
Reaction Conditions:
with polyphosphoric acid at 170; for 1.5 h;
Steps:
General procedure for the preparation of 2-(4-substitutedphenyl/benzyl)-5-aminobenzoxazoles(3a-3l)
General procedure: The derivatives were synthesized by heating 2,4-diaminophenoldihydrochloride (1) (0.01 mol) with suitable acid (2a-2l) (0.01 mol) in polyphosphoric acid (PPA) (24 g) and stirring at170-200 °Cfor 1.5-2.5 h.At the end of the reaction period, theresidue was poured into an ice-water mixture and neutralizedwith an excess of NaOH (10 %) solution, and the residue wasfiltered and boiled with charcoal (200 mg) in ethanol and filtered.After the evaporation of solvent in vacuo, the crudeproduct was obtained and recrystallized from ethanol-water(1:3) mixture (Yildiz-Oren et al., 2004a; Sener et al., 1987;Wynne et al., 2009).
References:
Ertan-Bolelli, Tugba;Yildiz, Ilkay;Ozgen-Ozgacar, Selda [Medicinal Chemistry Research,2016,vol. 25,# 4,p. 553 - 567]
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112606-69-6
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54995-50-5
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99-94-5
604 suppliers
$9.00/1g
54995-50-5
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$380.00/25g
99-57-0
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54995-50-5
28 suppliers
$380.00/25g