2,5-Dibromopyrimidine synthesis
- Product Name:2,5-Dibromopyrimidine
- CAS Number:32779-37-6
- Molecular formula:C4H2Br2N2
- Molecular Weight:237.88
7752-82-1
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$13.00/25g
32779-37-6
186 suppliers
$9.00/1g
Yield:32779-37-6 73.2%
Reaction Conditions:
Stage #1: 5-bromo-2-aminopyrimidinewith hydrogen bromide;bromine in water at 0 - 4;Inert atmosphere;
Stage #2: with sodium nitrite in water at 0 - 4; for 3 h;
Steps:
2 Example 2
Under nitrogen protection, 34.8 g (0.2 mol) of 2-amino-5-bromopyrimidine and 180 mL of 48% HBr aqueous solution were put into the reaction flask, and 48.0 g (0.3 mol) of bromine was added at 0-4°C to form a yellow suspension. 55.2 g (0.4 mol) of a 50% aqueous solution of sodium nitrite was added dropwise at a temperature of 0-4 °C. After the addition, the mixture was stirred at 0-4° C. for 3 h, the raw material was less than 3% detected by HPLC, and then poured into 100 mL of ice. Neutralize with 30% aqueous sodium hydroxide solution and adjust pH=10-11, and extract with dichloromethane, the organic phase is concentrated to no flow, and then recrystallized with 100 mL ethyl acetate: petroleum ether=1:4 to obtain a white solid 2,5-dibromopyrimidine 34.83 g, yield 73.2%,
References:
CN113683571,2021,A Location in patent:Paragraph 0031-0033
38353-09-2
396 suppliers
$5.00/5g
32779-37-6
186 suppliers
$9.00/1g
32779-36-5
615 suppliers
$5.00/5g
32779-37-6
186 suppliers
$9.00/1g
38353-06-9
319 suppliers
$15.00/1g
32779-37-6
186 suppliers
$9.00/1g
38353-06-9
319 suppliers
$15.00/1g
32779-37-6
186 suppliers
$9.00/1g