2,5-Dihydroxyxanthone synthesis
- Product Name:2,5-Dihydroxyxanthone
- CAS Number:35040-32-5
- Molecular formula:C13H8O4
- Molecular Weight:228.2
490-79-9
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120-80-9
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Yield:35040-32-5 81.7%
Reaction Conditions:
with zinc(II) chloride;trichlorophosphate at 75; for 0.5 h;Microwave irradiation;
Steps:
5.2.2. Synthesis of xanthones (3-1~3-33)
General procedure: The synthesis refers to a procedure described in literature [32].To a 50-mL flask 8 mL phosphorus oxychloride (POCl3) and anhydrouszinc chloride (6.8 g, 0.05 mol) were added. The suspensionwas stirred at 70 °C until ZnCl2 was completely dissolved intophosphorus oxychloride. The mixture was then cooled down toroom temperature (r.t.). Afterwards, salicylic acids (1a-l) (l.0 mmol)and phenolics (2a-d) (1.1 mmol) were added, respectively, and themixture was heated with microwave reactor with a programmedprocedure of 75 °C for 30 min. Then the mixture was cooled downto r.t. and pulled into ice water stirring for 20 min. The mixed solutionwasfiltered,washed with coldwater. The solid residues werecollected and purified by flash column liquid chromatography.
References:
Liu, Jie;Zhang, Jianrun;Wang, Huailing;Liu, Zhijun;Zhang, Cao;Jiang, Zhenlei;Chen, Heru [European Journal of Medicinal Chemistry,2017,vol. 133,p. 50 - 61]
35040-33-6
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35040-32-5
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1521-38-6
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129168-52-1
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7169-06-4
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