2,6-dichloro-4-(difluoromethoxy)pyridine synthesis
- Product Name:2,6-dichloro-4-(difluoromethoxy)pyridine
- CAS Number:1214379-42-6
- Molecular formula:C6H3Cl2F2NO
- Molecular Weight:213.9969
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Yield:1214379-42-6 740 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 50; for 4 h;
Steps:
10.1 Step 1: Synthesis of 2,6-dichloro-4-(difluoromethoxy)pyridine
Step 1: Synthesis of 2,6-dichloro-4-(difluoromethoxy)pyridine (0385) 720 mg (5.21 mmol) of potassium carbonate were added at room temperature to a mixed solution of 600 mg (3.66 mmol) of 2,6-dichloropyridin-4-ol, 1.08 g (5.32 mmol) of 2-bromo-2,2-difluoroethyl acetate and 15 ml N,N-dimethylformamide. After completion of the addition, said reaction mixture liquid was stirred for 4 hours at 50° C. After completion of the stirring, the reaction was stopped by addition of 30 ml of water, and said reaction liquid was extracted with ethyl acetate (2×30 ml). The organic layer obtained was dried with anhydrous sodium sulfate, and the solvent distilled off under reduced pressure. The residue obtained was purified by silica gel chromatography (n-hexane:ethyl acetate=99:1 to 90:10), and 740 mg of the desired compound were obtained as a colorless liquid.
References:
US2016/221998,2016,A1 Location in patent:Paragraph 0385
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