ChemicalBook >> CAS DataBase List >>Difluorochloromethane


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Modify Date:2022-12-21 16:56:50

Difluorochloromethane Properties

Melting point -146°C
Boiling point -40.8°C
Density 1,18 g/cm3
refractive index 1.2560
form Colorless, nearly odorless, nonflammable gas
Water Solubility Slightly soluble
Stability Stable.
FDA 21 CFR 701.30
CAS DataBase Reference 75-45-6(CAS DataBase Reference)
NIST Chemistry Reference Methane, chlorodifluoro-(75-45-6)
IARC 3 (Vol. 41, Sup 7, 71) 1999
EPA Substance Registry System HCFC-22 (75-45-6)


Risk and Safety Statements

Hazard Codes  F,N
Risk Statements  40-59
Safety Statements  23-59
RIDADR  1018
Hazard Note  Non-Flammable
DOT Classification 2.2 (Nonflammable gas)
HazardClass  2.2
Toxicity LCLo inhalation in dog: 70pph
NFPA 704
1 1

Difluorochloromethane Chemical Properties,Uses,Production

Chemical Properties

Chlorodifluoromethane is a nonflammable, colorless, nearly odorless gas.

Chemical Properties

colourless gas


Aerosol propellant; refrigerant; lowtemperature solvent


Refrigerant, low-temperature solvent, fluorocarbon resins, especially tetrafluoroethylene polymers.

General Description

Difluorochloromethane is a colorless gas with an ethereal odor. Difluorochloromethane is shipped as a liquefied gas under its own vapor pressure. Difluorochloromethane is noncombustible. Difluorochloromethane can asphyxiate by the displacement of air. Contact with the liquid can cause frostbite. Toxic gases can be produced in fires involving Difluorochloromethane. Exposure of the container to prolonged heat or fire may cause Difluorochloromethane to rupture violently and rocket.

Air & Water Reactions

The liquefied gas poured into water can be violently explosive. This is due to the phase transition from superheated liquid to vapor.

Reactivity Profile

Difluorochloromethane is incompatible with the following: Alkalis, alkaline earth metals (e.g., powdered aluminum, sodium, potassium, zinc) .


Asphyxiant. Central nervous system impairment, cardiac sensitization. Questionable carcinogen.

Health Hazard

Inhalation at greater than 10% concentration in air may cause narcosis. Liquid may cause frostbite.

Fire Hazard

Special Hazards of Combustion Products: Decomposition gases are toxic and irritating.

Safety Profile

Mddly toxic by inhalation. Experimental reproductive effects. Mutation data reported. An asphpant in hgh concentrations. At elevated pressures, 50% mixtures with air are combustible although ignition is dfficult. When heated to decomposition it emits toxic fumes of Fand Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and FLUORIDES.

Potential Exposure

Chlorodifluoromethane is used as an aerosol propellant, refrigerant, and low-temperature solvent. It is used in the synthesis of polytetrafluoroethylene (PTFE).


In one study, an oral dose of 300mg of HCFC 22/kg of body weight was given to 36 male and 36 female rats 5 days/week for 52 weeks. The rats were held for 125 weeks compared to controls. There was no evidence of any treatment related increase in tumors. In an inhalation study 60 male and 60 female rats were exposed by inhalation to levels of 5000 ppm of HCFC 22. The exposures were 4 h/day, 5 days/week for 104 weeks (rats) or 78 weeks (mice).


UN1018 Chlorodifluoromethane, Hazard Class: 2.2; Labels: 2.2-Non-flammable compressed gas. Cylinders must be transported in a secure upright position, in a wellventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.


The liquefied gas poured into water can be violently explosive. This is due to the phase transition from superheated liquid to vapor. Chlorodifluoromethane reacts violently with alkalies and alkaline earth metals; powdered aluminum; sodium, potassium, and zinc; causing fire and explosion hazard. Moisture and rust cause slow decomposition, forming toxic gases. Attacks some plastics, rubber, and coatings. Decomposes in heat forming fumes of chlorine, hydrogen chloride, HF, and phosgene. Attacks magnesium and its alloys.

Waste Disposal

Return refillable compressed gas cylinders to supplier. Return to vendor or send to licensed waste disposal company.

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