ChemicalBook CAS DataBase List 2,6-DIMETHYLPHENYLMETHYLSULFONE

2,6-DIMETHYLPHENYLMETHYLSULFONE synthesis

11synthesis methods

Product Name:2,6-DIMETHYLPHENYLMETHYLSULFONE
CAS Number:97416-12-1
Molecular formula:C9H12O2S
Molecular Weight:184.26

4163-79-5 Synthesis

4163-79-5
12 suppliers
$916.84/5G

97416-12-1
17 suppliers
$300.00/10g

Yield:97416-12-1 86.5%

Reaction Conditions:

with Peroxyacetic acid in dichloromethane;water monomer;

Steps:

S2 S2, oxidation

Take solid 2,6-dimethylmethyl mercaptobenzene in the reaction flask, add dichloromethane and stir to dissolve, dropwise add aqueous peroxyacetic acid at room temperature, TLC monitoring until the raw material disappears; add dichloromethane and deionized water, in Separate the liquid in a separatory funnel, extract the aqueous phase twice with dichloromethane, combine the organics, dry, and spin-dry to obtain a solid 2,6-dimethylmethanesulfonylbenzene.The reaction equation is:Further, the molar ratio of 2,6-dimethylmercaptobenzene to peroxyacetic acid is 1:1.86;Further, the preparation process of peroxyacetic acid is: adding 125 g of hydrogen peroxide with a mass concentration of 30% to 1-2 ml of concentrated sulfuric acid, stirring at room temperature and dropping 75 g of glacial acetic acid, and stirring for 12 hours.In this example, specifically, take 3.6836 g (20 mmol) of solid 2,6-dimethylmethyl mercaptobenzene in a single-necked bottle, add 10 ml of dichloromethane and stir to dissolve, and dropwise add 2 mol/L peroxygen at room temperature The acetic acid aqueous solution was monitored by TLC until the raw material disappeared. The amount of peracetic acid aqueous solution was 18.6 mL; 20 mL of dichloromethane and 10 mL of deionized water were added, and the liquid was separated in a separatory funnel. The aqueous phase was extracted twice with 10 mL of dichloromethane and combined Organic, dried and spin-dried to give solid 2,6-dimethylmethanesulfonylbenzene. The yield was 86.5%.

References:

CN111170908,2020,A Location in patent:Paragraph 0030-0036