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Methanesulfonyl chloride

Methanesulfonyl chloride
Methanesulfonyl chloride structure
Chemical Name:
Methanesulfonyl chloride
MSC;MSCI;MSCL;ABF1;ABF-1;124-63-0;CH3SO2Cl;JACS-124-63-0;MESYL CHLORIDE;methanesulfonyl
Molecular Formula:
Formula Weight:
MOL File:

Methanesulfonyl chloride Properties

Melting point:
Boiling point:
60 °C21 mm Hg(lit.)
1.48 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
>230 °F
storage temp. 
Store at R.T.
Water Solubility 
Miscible with alcohol, ether and organic solvents. Immiscible with water.
Moisture Sensitive
CAS DataBase Reference
124-63-0(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
EWG's Food Scores
NIST Chemistry Reference
Methanesulfonyl chloride(124-63-0)
EPA Substance Registry System
Methanesulfonyl chloride (124-63-0)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H300+H310+H330-H314-H335-H300-H310-H318-H330
Precautionary statements  P301+P310a-P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a-P260-P264-P280-P284-P301+P310-P302+P350
Hazard Codes  T+,T,C
Risk Statements  24/25-26-34-37-35-22-41
Safety Statements  26-28-36/37/39-45-25-28A
RIDADR  UN 3246 6.1/PG 1
WGK Germany  2
RTECS  PB2790000
Hazard Note  Toxic/Corrosive
HazardClass  6.1
PackingGroup  I
HS Code  29049095

Methanesulfonyl chloride price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 471259 Methanesulfonyl chloride ≥99.7% 124-63-0 1l $151 2020-08-18 Buy
Sigma-Aldrich 471259 Methanesulfonyl chloride ≥99.7% 124-63-0 2l $225 2018-11-20 Buy
Alfa Aesar A13383 Methanesulfonyl chloride, 98% 124-63-0 500g $61.9 2020-06-24 Buy
Alfa Aesar A13383 Methanesulfonyl chloride, 98% 124-63-0 100g $18.7 2020-06-24 Buy
Sigma-Aldrich 471259 Methanesulfonyl chloride ≥99.7% 124-63-0 5ml $25.7 2020-08-18 Buy

Methanesulfonyl chloride Chemical Properties,Uses,Production

Chemical Properties

Colorless to yellow liquid

Chemical Properties

Pale yellow corrosive liquid. Unpleasant, pungent odor.


In the synthesis of photographic and agricultural chemicals, pharmaceutical intermediates. As a stabilizer; catalyst; curing and chlorinating agent; precursor to methanesulfonic acid.

General Description

A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.

Reactivity Profile

Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Potential Exposure

Chemical intermediate in various industries including pesticides, flame retardants, pharmaceuticals, plastics. A solvent, curing agent, and chemical stabilizer. Laboratory chemical.


UN3246 Methanesulfonyl chloride, Hazard Class 6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive material, Inhalation Hazard Zone B.

Purification Methods

Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]


Vapors may form explosive mixture with air. Slowly reacts with water, releasing toxic and corrosive hydrogen chloride gas. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, DMSO, ethers, strong acids, strong bases.

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed

Methanesulfonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Related articles

Methanesulfonyl chloride Spectrum

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