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ChemicalBook CAS DataBase List 2'-Ac-Docetaxel
151509-27-2

2'-Ac-Docetaxel synthesis

10synthesis methods
Benzenepropanoic acid, α-(acetyloxy)-β-[bis[(1,1-dimethylethoxy)carbonyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

1227402-72-3
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2'-Ac-Docetaxel

151509-27-2
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Yield:151509-27-2 88.9%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20;

References:

Shen, Xin;Yang, Jidong;Zhan, Huaxing;Wang, Hu;Wu, Shaohong;Chen, Zili [Chinese Journal of Chemistry,2013,vol. 31,# 1,p. 31 - 36]