ChemicalBook CAS DataBase List 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine

2-Amino-3-bromo-5-(trifluoromethyl)-pyridine synthesis

2synthesis methods

Product Name:2-Amino-3-bromo-5-(trifluoromethyl)-pyridine
CAS Number:79456-30-7
Molecular formula:C6H4BrF3N2
Molecular Weight:241.01

74784-70-6 Synthesis

74784-70-6
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$5.00/1g

2-Amino-3-bromo-5-(trifluoromethyl)-pyridine

79456-30-7
122 suppliers
$6.00/250mg

Yield:79456-30-7 94.17%

Reaction Conditions:

with N-Bromosuccinimide in tetrahydrofuran at 0 - 20; for 1 h;Temperature;Solvent;

Steps:

57; 63 3-Bromo-5-(trifluoromethyl)pyridin-2-amine

To a solution of 5- (trifluoromethyl)pyridin-2-amine (10 g, 61.69 mmol) in THF (100 mL) was added NBS (11.53 g, 64.77 mmol) portionwise at 0 °C and the mixture was stirred at 20 °C for 1 h. The mixture was concentrated under vacuum and purified by silica gel column chromatography to give 3-bromo- 5-(trifhioromethyl)pyridin-2-amine (14 g, 58.09 mmol, 94.17% yield).

References:

WO2020/219871,2020,A1 Location in patent:Paragraph 00499; 00529

2-Pyridinamine, 3,6-dichloro-5-(trifluoromethyl)-

79456-29-4
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74784-70-6 Synthesis

74784-70-6
322 suppliers
$5.00/1g

79456-30-7
122 suppliers
$6.00/250mg

References

2-Amino-3-bromo-5-(trifluoromethyl)-pyridine Related Search:

2-AMINO-3-CHLORO-5-NITROPYRIDINE 2-AMINO-3-IODO-5-NITROPYRIDINE 2-Amino-3-bromo-5-nitropyridine 3-iodo-5-(trifluoromethyl)-2-pyridinylamine 5-(Trifluoromethyl)pyridin-2-amine 3-Bromo-5-(trifluoromethyl)pyridine