2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE synthesis
- Product Name:2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE
- CAS Number:7144-20-9
- Molecular formula:C8H11N3O
- Molecular Weight:165.19
34570-17-7
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123-54-6
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Yield: 100%
Reaction Conditions:
with potassium hydroxide in methanol at 20;Inert atmosphere;
Steps:
7.1 4.1.7.1. Synthesis of 2-amino-4,6-dimethylnicotinamide(31b).
Malonamidine hydrochloride (30) (20.4 g, 148.4 mmol)was dissolved in 1 L of methanol. After addition of acetylacetone(15.3 ml, 148 mmol) and KOH pellets (9.99 g, 178 mmol) the mixturewas stirred for 24 h at rt. Evaporation gave 24.5 g (100%) of theproduct as a white solid. MS (ESI): 166.6 [M+H]+.
References:
Miltz, Wolfgang;Velcicky, Juraj;Dawson, Janet;Littlewood-Evans, Amanda;Ludwig, Marie-Gabrielle;Seuwen, Klaus;Feifel, Roland;Oberhauser, Berndt;Meyer, Arndt;Gabriel, Daniela;Nash, Mark;Loetscher, Pius [Bioorganic and Medicinal Chemistry,2017,vol. 25,# 16,p. 4512 - 4525] Location in patent:supporting information
28491-67-0
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inquiry
7144-20-9
61 suppliers
$240.00/1g
123-54-6
559 suppliers
$10.00/25ml
7144-20-9
61 suppliers
$240.00/1g