2-Amino-4-bromo-3-fluorobenzoic acid synthesis
- Product Name:2-Amino-4-bromo-3-fluorobenzoic acid
- CAS Number:1416013-62-1
- Molecular formula:C7H5BrFNO2
- Molecular Weight:234.02
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
1336963-95-1
71 suppliers
$58.00/100mg
1416013-62-1
154 suppliers
$8.00/100mg
Yield:1416013-62-1 94%
Reaction Conditions:
with dihydrogen peroxide;sodium hydroxide at 0 - 20; for 16 h;
Steps:
1 2-Amino-4-bromo-3-fluorobenzoic acid
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
References:
WO2016/164675,2016,A1 Location in patent:Page/Page column 231-232
194804-91-6
143 suppliers
$18.00/100mg
1416013-62-1
154 suppliers
$8.00/100mg
58534-95-5
183 suppliers
$8.00/1g
1416013-62-1
154 suppliers
$8.00/100mg
58534-94-4
192 suppliers
$10.00/1g
1416013-62-1
154 suppliers
$8.00/100mg
1336963-99-5
5 suppliers
inquiry
1416013-62-1
154 suppliers
$8.00/100mg