2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE synthesis
- Product Name:2-AMINO-4-PHENOXY-6-METHYLPYRIMIDINE
- CAS Number:22370-25-8
- Molecular formula:C11H11N3O
- Molecular Weight:201.22
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Yield:22370-25-8 89%
Reaction Conditions:
with potassium hydroxide in water at 165; for 0.0833333 h;Microwave;
Steps:
1.b
Example 1 (b): Synthesis of 4-methyl-6-aryloxy-pyrimidin-2- ylamines (3) (4) 4-METHYL-6-PHENOXY-PYRIMIDIN-2-YLAMINE (4A) In a Microwave vial (5 mL) was placed 2-amino-4-chloro-6- methylpyrimidine (143 mg), phenol (3A, 94 mg), 2M potassium hydroxide (500 PL) and water (3.5 mL). The vessel was sealed with a crimped septum cap, and placed in the microwave cavity. The vial was heated to 165°C for 5 minutes, after this time the vial was allowed to cool to room temperature, whereupon a solid precipitated. The solid was collected by filtration and dried in a heated DESICCATOR to give the title compound (180 mg, 89 W) as a white solid. LC/MS System B: Rt = 3.07 min, m/z (ES+) = 202 ((M+H) for C11H11N3O).
References:
WO2005/12263,2005,A1 Location in patent:Page/Page column 79-80
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