2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE synthesis
- Product Name:2-AMINO-5-BROMOTHIAZOLO[5,4-B]PYRIDINE
- CAS Number:934266-82-7
- Molecular formula:C6H4BrN3S
- Molecular Weight:230.09
1112982-76-9
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$45.00/50mg
934266-82-7
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$23.00/250mg
Yield:934266-82-7 93%
Reaction Conditions:
Stage #1: N-(5-bromothiazolo[5,4-b]pyridin-2-yl)acetamidewith hydrogenchloride;water for 1 h;Reflux;
Stage #2: in water at 20; pH=10;
Steps:
4; 4.4-ii
As shown in step 4-ii of Scheme 21, Compound 1005 (5.44 g, 20 mmol) was suspended in 6 N HCl (100 mL). The reaction mixture was heated at reflux for 1 h, at which time all of the material went into solution. The mixture was cooled to RT and the reaction was made basic to a pH of 10, at which time the product precipitated out. The solid was collected on a fritted funnel and dried to afford 5-bromothiazolo[5,4-δ]pyridin-2-amine (Compound 1006, 4.35 g, 93% yield): ESMS (M+H) 230, 232; 1H NMR (DMSO-d6) δ 7.9 (br, 2H), 7.6 (d, IH), 7.4 (d, IH).
References:
WO2009/129211,2009,A1 Location in patent:Page/Page column 35; 37
13534-97-9
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333-20-0
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934266-82-7
57 suppliers
$23.00/250mg
13534-97-9
420 suppliers
$6.00/1g
934266-82-7
57 suppliers
$23.00/250mg
169833-70-9
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$9.00/250mg
934266-82-7
57 suppliers
$23.00/250mg
5418-51-9
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934266-82-7
57 suppliers
$23.00/250mg