2-AMINO-N-(4-METHOXYBENZYL)BENZAMIDE synthesis
- Product Name:2-AMINO-N-(4-METHOXYBENZYL)BENZAMIDE
- CAS Number:221539-30-6
- Molecular formula:C15H16N2O2
- Molecular Weight:256.3
118-48-9
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221539-30-6
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Yield:221539-30-6 99.1%
Reaction Conditions:
in ethyl acetate at 40; for 3 h;
Steps:
2.2.1. Synthesis of 2-amino-N-(4-methoxybenzyl)benzamide ( 3 )
Ethyl acetate (300 mL) and isatoic anhydride (50 g, 0.31 mol) were added to a 500 mL single-neck flask. Subsequently (4- methoxyphenyl)methanamine (40.04 mL, 0.31 mol) was slowly added under stirring at room temperature. After the addition was completed, temperature of the reaction solution was heated to 40 °C, and the reactional time was monitored by TLC using mixture of petroleum ether and ethyl acetate (1:1) and the plates were re- vealed with sublimated iodine supported on silica gel. After the re- action was stirred for 3 h, the mixture was cooled to room temper- ature. The reaction precipitated white solid and was filtered. The filter cake was slurried twice with water and methanol in turn. Af- ter the filter cake was dried to obtain the compound 3 (77.79 g, yield 99.1%) as white solid.
References:
Chen, Dong-Mei;Chen, Yu-Mei;Liao, Tian-Hui;Liao, Wei-Ke;Wang, Zhong-Yuan;Ye, Wen-Jun;Zhao, Chun-Shen;Zhou, Zhi-Xu [Journal of Molecular Structure,2022,vol. 1250,art. no. 131796]
2393-23-9
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552-89-6
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221539-30-6
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$85.00/250mg
5344-90-1
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2393-23-9
478 suppliers
$20.00/25g
221539-30-6
21 suppliers
$85.00/250mg