ChemicalBook CAS DataBase List 2-Aminobenzyl alcohol

2-Aminobenzyl alcohol synthesis

10synthesis methods

Product Name:2-Aminobenzyl alcohol
CAS Number:5344-90-1
Molecular formula:C7H9NO
Molecular Weight:123.15

552-89-6
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5344-90-1
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$6.00/5g

Yield:5344-90-1 97%

Reaction Conditions:

with sodium tetrahydridoborate;copper in lithium hydroxide monohydrate at 80; for 0.0833333 h;Green chemistry;

Steps:

A typical procedure for reduction of nitrobenzeneto aniline with NaBH4/Cu NPs system

General procedure: In a round-bottom flask (10 mL) equipped with a magneticstirrer, a mixture of nitrobenzene (0.123 g, 1 mmol)and H2O (2 mL) was prepared. Cu NPs (0.0095 g,15 mmol %) was then added, and the mixture was stirredfor 3 min at 80 °C. Afterward, NaBH4 (0.076 g, 2 mmol)was added portion wisely (two portions) with the intervalof 2 min, and the resulting mixture was continued to stirringat 80 °C. TLC monitored the progress of the reaction(n-hexane/EtOAc: 5/2). After completion of the reaction,Cu NPs was separated by filtration, and the mixture wasextracted with EtOAc (2 × 5 mL). The organic layer wasthen dried over anhydrous Na2SO4. Evaporation of the solventaffords the pure liquid aniline in 91 % yield (0.085 g,Table 2, entry 1).

References:

Zeynizadeh, Behzad;Zabihzadeh, Mehdi;Shokri, Zahra [Journal of the Iranian Chemical Society,2016,vol. 13,# 8,p. 1487 - 1492]