2-AMINO-N-FURAN-2-YLMETHYL-BENZAMIDE synthesis
- Product Name:2-AMINO-N-FURAN-2-YLMETHYL-BENZAMIDE
- CAS Number:117507-63-8
- Molecular formula:C12H12N2O2
- Molecular Weight:216.24
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Yield:117507-63-8 94%
Reaction Conditions:
with trimethylaluminum in toluene at 20 - 100; for 5 h;
Steps:
32
Example 32 [0307] methyl 2-aminobenzoate (0.857 mL, 6.62 mmol) and furan-2-ylmethanamine (1.84 mL, 19.9 mmol) in toluene (20.0 mL) was treated at room temperature with AlMe3 (6.62 mL, 2.0 M in toluene, 13.2 mmol). The reaction mixture was stirred at 100° C. for 5 h and then quenched with water after cooling to room temperature. The reaction mixture was concentrated in vacuo and the crude residue was purified via silica gel chromatography using a gradient of 0-80% of EtOAc in hexanes to give 1.35 g (94%) of the title compound as a white solid. LC-MS Retention Time: t1 (Method 1)=3.644 min.
References:
US2015/119426,2015,A1 Location in patent:Paragraph 0307-0308
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552-89-6
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![N-[(furan-2-yl)methyl]-2-nitrobenzamide](/CAS/20180713/GIF/120275-54-9.gif)
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117507-63-8
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117507-63-8
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