2-AMINO-N-PHENYL-BENZENESULFONAMIDE synthesis
- Product Name:2-AMINO-N-PHENYL-BENZENESULFONAMIDE
- CAS Number:27332-20-3
- Molecular formula:C12H12N2O2S
- Molecular Weight:248.3
5454-97-7
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27332-20-3
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Yield:27332-20-3 91%
Reaction Conditions:
with sodium tetrahydroborate;nickel(II) chloride hexahydrate in methanol;dichloromethane at 0 - 20; for 0.5 h;
Steps:
4.1.3. General procedure for intermediates 20-31
To a solution of 12 (25.0 g, 89.9 mmol, 1.0 eq) and NiCl2.6H2O(42.8 g, 180 mmol, 2.0 eq) in DCM (300 mL) and MeOH (100 mL)was added NaBH4 (13.7 g, 360 mmol, 4.0 eq) carefully at 0° C. The resultant mixture was stirred at room temperature for 0.5 h and the solvent was removed under reduced pressure. The residue was then extracted with EA before filtration, and the filtrate was washed successively with H2O and brine. After being dried over anhydrous Na2SO4, the organic layer was concentrated in vacuo to afford a clear and viscous oil that was slowly solidified. Yield 91%.
References:
Ma, Xiaodong;Wei, Jun;Wang, Chang;Gu, Dongyan;Hu, Yongzhou;Sheng, Rong [European Journal of Medicinal Chemistry,2019,vol. 170,p. 112 - 125]
1694-92-4
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27332-20-3
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62-53-3
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27332-20-3
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101954-71-6
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27332-20-3
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