2-Aminobenzenesulfonamide synthesis
- Product Name:2-Aminobenzenesulfonamide
- CAS Number:3306-62-5
- Molecular formula:C6H8N2O2S
- Molecular Weight:172.2
5455-59-4
3306-62-5
General procedure for the synthesis of o-aminobenzenesulfonamide from 2-nitrobenzenesulfonamide: 2-nitrobenzenesulfonamide (80.0 g, 0.58 mol) was dissolved in methanol in the presence of a Pd/C catalyst (10.0 g, 13% w/w) to prepare a solution with a mass concentration of 10%. The hydrogenation reaction was carried out at 50 psi hydrogen pressure and 60°C and the reaction was continued overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give 60 g of off-white solid o-aminobenzenesulfonamide in 95% yield.
5455-59-4
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3306-62-5
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Yield:3306-62-5 95%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 60; under 2585.81 Torr;
Steps:
2 Synthesis of 2 - Aminobenzenesulfonamide
A solution of 2-nitrobenzenesulfonamide (compound 2) (80.0 g, 0.58 mol) in methanol at 50 psi in the presence of catalyst Pd / C (10.0 g, 13% w / w) at a mass concentration of 10%2Followed by hydrogenation at 60 ° C overnight. The catalyst was removed by filtration and the filtrate was concentrated to give 60 g of an off-white solid 2-aminobenzenesulfonamide (Compound 3) in a yield of 95%.
References:
CN104761514,2016,B Location in patent:Paragraph 0028-0030
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