2-BROMO-1-(3,5-DIMETHOXYPHENYL)ETHANONE synthesis
- Product Name:2-BROMO-1-(3,5-DIMETHOXYPHENYL)ETHANONE
- CAS Number:50841-50-4
- Molecular formula:C10H11BrO3
- Molecular Weight:259.1
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Yield:50841-50-4 90%
Reaction Conditions:
with tetra-N-butylammonium tribromide in tetrahydrofuran;methanol at 20; for 2 h;Solvent;Concentration;
Steps:
1.1; 2
(1) 100g of 3,5-dimethoxyacetophenone (MW: 180.20, 0.55mol)Add 300mL tetrahydrofuran and 100mL methanol into a three-necked flask,Add 294g (MW: 482.18, 0.61mol) tetrabutylammonium tribromide,The reaction was stirred at room temperature for 2h. After the reaction,Add 1L isopropanol and 1L purified water to the system,Stir and crystallize in an ice-water bath for 2h, filter under reduced pressure,The filter cake was air-dried at 50°C for 8 hours to obtain 129g of light yellow solid(90% molar yield).
References:
CN112209841,2021,A Location in patent:Paragraph 0054-0056; 0061-0074
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7789-45-9
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17213-57-9
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