2-BroMo-1,3,5-triphenylbenzene synthesis
- Product Name:2-BroMo-1,3,5-triphenylbenzene
- CAS Number:10368-73-7
- Molecular formula:C24H17Br
- Molecular Weight:385.3
612-71-5
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10368-73-7
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Yield: 93%
Reaction Conditions:
with bromine;acetic acid in dichloromethane at 40; for 16 h;
Steps:
2 2-bromo-1,3,5-triphenylbenzene [12]
Bromine (3.2 g, 20 mmol) was slowly added to a stirred suspension of 1,3,5- triphenylbenzene (5.1 g, 17 mmol) in dichloromethane (30 ml) and acetic acid (6 ml). It was stirred at 40°C for 16 h. Water (30 ml) was added and excess bromine was quenched with solid Na2SO3. It was alkalised with 25% NH3aq and layers were separated. The organic layer was washed with 0.1 M NH3aq, dried with MgSO4 and evaporated. The residue was recrystallized from tBuOMe and ethnanol. The precipitated solid was filtered off and washed with ethanol. Yield: 5.97 g (93 %).
References:
MERCK PATENT GMBH WO2021/58406, 2021, A1 Location in patent:Page/Page column 97
75-15-0
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612-71-5
185 suppliers
$13.00/10g
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1000210-73-0
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10368-73-7
70 suppliers
$6.00/100mg