Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-broMo-1-ethyl-4-nitrobenzene

2-broMo-1-ethyl-4-nitrobenzene synthesis

2synthesis methods
-

Yield:52121-34-3 98%

Reaction Conditions:

with sulfuric acid;bromine;silver sulphate in lithium hydroxide monohydrate at 20;

Steps:

27.a 2- bromo-1 -ethyl-4-nitrobenzene

Example 27 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-ethylquinolin-4-yl)amino)-5- cvclopentylbenzoic acid 2- bromo-1 -ethyl-4-nitrobenzene. To a mixture of 1 -ethyl-4-nitrobenzene (4.0 g, 26.4 mmol), silver sulfate (8.18 g, 26.4 mmol), concentrated sulphuric acid (24 mL) and water (2.8 mL), was added bromine (4.23 g, 26.4 mmol) dropwise at ambient temperature. After the addition, the mixture was stirred for 4 h at ambient temperature, then poured into dilute sodium hydrogen sulfite solution (10%, 150 mL) and extracted with ethyl acetate (300 mL x 3). The extracts were dried over Na2S04. The solvent was concentrated under vacuum to provide the title compound (5.95 g, 98%). 1H NMR (300 MHz, DMSO-d6) ppm 1.20 (t, J=7.5 Hz, 3 H), 2.82 (q, J=7.5 Hz, 2 H), 7.65 (d, J=8.4 Hz, 1 H), 8.19 (dd, J=2.4, 8.4 Hz, 1 H), 8.38 (d, J=2.4 Hz, 1 H).

References:

WO2013/96151,2013,A1 Location in patent:Page/Page column 91

2-broMo-1-ethyl-4-nitrobenzene Related Search: