2-bromo-1-methoxynaphthalene synthesis
- Product Name:2-bromo-1-methoxynaphthalene
- CAS Number:62012-54-8
- Molecular formula:C11H9BrO
- Molecular Weight:237.09
771-15-3
120 suppliers
$16.00/250mg
74-88-4
353 suppliers
$15.00/10g
62012-54-8
84 suppliers
$61.00/100mg
Yield:62012-54-8 85.6%
Reaction Conditions:
with potassium hydroxide in acetonitrile at 40; for 12 h;
Steps:
4.3.1.2. 2-Bromo-1-methoxynaphthalene (16)
A solution of 15 (10 g,44.83 mmol), potassium hydroxide (5.03 g, 89.66 mmol), and methyliodide (16.74 mL, 268.98 mmol) in acetonitrile (80 mL) was stirred at40 °C for 12 h. The mixture was washed with water, extracted withdichloromethane, dried over anhydrous sodium sulfate andconcentrated in vacuo. The crude product was purified by silica gelcolumn eluting with petroleum ether: ethyl acetate (20/1) to give thedesired product (9.1 g, yield 85.6%) as a white solid. Rf=0.5 (1:6,ethyl acetate:petroleum ether). 1H NMR (400 MHz, CDCl3) δ 8.14 (d,J=7.2 Hz, 1H), 7.83 (d, J=7.2 Hz,1H), 7.59 - 7.49 (m, 4H), 4.01 (s,3H).
References:
He, Yulong;Dou, Huixia;Gao, Dingding;Wang, Ting;Zhang, Mingming;Wang, Heyao;Li, Yingxia [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 19,art. no. 115015]
2216-69-5
269 suppliers
$5.00/10g
5467-58-3
140 suppliers
$9.00/1g
62012-54-8
84 suppliers
$61.00/100mg
90-15-3
753 suppliers
$9.00/5g
62012-54-8
84 suppliers
$61.00/100mg