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ChemicalBook CAS DataBase List 2-Bromo-3,4,5,6-tetrafluorobenzonitrile
16583-02-1

2-Bromo-3,4,5,6-tetrafluorobenzonitrile synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: aq. HNO3, H2SO4
2: Sn, aq. HCl
3: Br2 / Heating
4: aq. H2SO4 / Heating
5: dimethylformamide / Heating
6: (i) NaNO2, liq. HF, (ii) CuBr, aq. HBr

References:

Belf,L.J. et al. [Tetrahedron,1967,vol. 23,p. 4719 - 4727]