2'-BROMO-4'-FLUOROACETOPHENONE synthesis
- Product Name:2'-BROMO-4'-FLUOROACETOPHENONE
- CAS Number:1006-39-9
- Molecular formula:C8H6BrFO
- Molecular Weight:217.04
261711-20-0
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1006-39-9
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Yield:1006-39-9 92%
Reaction Conditions:
with pyridinium chlorochromate in dichloromethane at 20; for 2 h;
Steps:
23 Synthesis of Compound (34):
To a solution of compound (33) (1.83 g, 8.35 mmol) in dry CH2Cl2 (41.75 mL) was added a mixture of pyridinium chlorochromate (PCC) (5.4 g, 25.1 mmol). The resulting suspension was stirred at room temperature for 2 hours, filtered through a pad of silica gel, washed with CH2Cl2 and concentrated in vacuo. The crude product was purified by flash column chromatography to afford the compound (34) in a yield of 92%. (0262) Spectral data of compound (34): 1H NMR (400 MHz, CDCl3): δ 7.54 (dd, J=8.6, 5.9 Hz, 1H), 7.35 (dd, J=8.3, 2.5 Hz, 1H), 7.08 (ddd, J=8.6, 7.7, 2.5 Hz, 1H), 2.62 (s, 3H). 19F NMR (376 MHz, CDCl3): δ -107.01 (s, 1F).
References:
US9896467,2018,B1 Location in patent:Page/Page column 62; 63
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