2-Bromo-5-chloronitrobenzene synthesis
- Product Name:2-Bromo-5-chloronitrobenzene
- CAS Number:41513-04-6
- Molecular formula:C6H3BrClNO2
- Molecular Weight:236.45
6280-88-2
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41513-04-6
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Yield:41513-04-6 96%
Reaction Conditions:
with trichloroisocyanuric acid;bromine in tetrachloromethane at 10 - 100; for 18 h;Photolysis;
Steps:
4 Bromodecarboxylation of nitroarenecarboxylic acids
General procedure: A 25 mL round bottom flask equipped with Dimroth condenser (chilled to 10 °C) was charged with nitroarenecarboxylic acid ArC02H (1.8 mmol), chloroisocyanurate, brominating agent and solvent (8 mL). The mixture was stirred and heated in an oil bath under fluorescent room light irradiation (FL). The cooled reaction mixture was filtered through short silica gel pad, washed with 1 M aq Na2S03, dried over Na2S04, filtered and concentrated in vacuo to obtain bromonitroarene ArBr. The obtained product contained between 1-5% of the corresponding chloronitroarene ArCl as a by-product. The results are presented in Table 2. Table 2. Bromodecarboxylation of nitroarenecarboxylic acids ArC02H a
References:
WO2017/60906,2017,A1 Location in patent:Paragraph 00122
89-63-4
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106-39-8
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23082-51-1
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41513-04-6
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