ChemicalBook CAS DataBase List 4-Bromochlorobenzene

4-Bromochlorobenzene synthesis

13synthesis methods

Product Name:4-Bromochlorobenzene
CAS Number:106-39-8
Molecular formula:C6H4BrCl
Molecular Weight:191.45

1679-18-1 Synthesis

1679-18-1
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106-39-8
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$14.00/5g

Yield:106-39-8 93%

Reaction Conditions:

with sodium nitrite in acetonitrile at 80; for 1 h;Sealed tube;

Steps:

General procedure for the ipso-bromination of arylboronic acids

General procedure: In a pressure tube, to a solution of a selected arylboronic acid (0.25 mmol) and sodium nitrate (4.3 mg, 0.063 mmol) in dry acetonitrile (2 mL), PVP-Br 2 (1:1) (89 mg, 0.34 mmol) was added. The reaction mixture was stirred vigorously at 80 C for required time. Upon completion, the reaction mixture was diluted with dichloromethane and filtered through celite, washing with more dichloromethane. The filtrate was washed with Na2S2O4 solution, saturated NaCl solution and dried over anhydrous Na2SO4. Removal of the solvent under reduced pressure afforded the product in pure form, as verified by 1H NMR and 13C NMR.

References:

Fu, Fang;Gurung, Laxman;Czaun, Miklos;Mathew, Thomas;Prakash, G.K. Surya [Tetrahedron Letters,2019,vol. 60,# 38,art. no. 151020] Location in patent:supporting information

106-47-8 Synthesis