ChemicalBook CAS DataBase List 2-Bromo-5-ethynylpyridine

2-Bromo-5-ethynylpyridine synthesis

1synthesis methods

Product Name:2-Bromo-5-ethynylpyridine
CAS Number:569672-28-2
Molecular formula:C7H4BrN
Molecular Weight:182.02

The iodobromopyridine (2-Bromo-5-iodopyridine), the starting material, was coupled with TMS-acetylene under Sonogashira conditions. One-pot deprotection and recrystallization could yield the bromo,ethynyl-functionalized pyridine (2-Bromo-5-ethynylpyridine)[1].

73290-22-9 Synthesis

73290-22-9
328 suppliers
$6.00/1g

1066-54-2
464 suppliers
$9.00/10g

569672-28-2
43 suppliers
$165.00/250mg

Yield:569672-28-2 81%

Reaction Conditions:

with copper(l) iodide;tetrakis(triphenylphosphine) palladium⁽⁰⁾;triethylamine in toluene at 60;Sonogashira cross-coupling;

References:

Grave, Christian;Lentz, Dieter;Schaefer, Andreas;Samori, Paolo;Rabe, Juergen P.;Franke, Peter;Schlueter, A. Dieter [Journal of the American Chemical Society,2003,vol. 125,# 23,p. 6907 - 6918]