2-Bromo-5-fluorobenzylamine synthesis
- Product Name:2-Bromo-5-fluorobenzylamine
- CAS Number:747392-34-3
- Molecular formula:C7H7BrFN
- Molecular Weight:204.04
57381-39-2
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747392-34-3
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Yield:747392-34-3 55.5%
Reaction Conditions:
with sodium tetrahydroborate;trifluoroacetic acid in tetrahydrofuran at 20; for 16 h;
Steps:
346.B Step B: (2-Bromo-5-fluorophenyl)methanamine
To a solution of 2-bromo-5-fluorobenzonitrile (3.0g, 15.00mmol) and NaBH4 (1.419 g, 37.5 mmol) in THF (30mL) was slowly added TFA (3.47 ml., 45.0 mmol) over a period of20 min. The resulting mixture was stirred at rt for 16 hours, then MeOH (10 mL) was added and the mixture wasstirred for another 30 min. It was then diluted with EtOAc(200 ml.), washed with water, dried over Na2S04 and evaporated.The residue was purified on an 80 g Thompson silicacartridge (3% to 100% B in Hexanes, 1200 ml., B: 10%MeOH in EtOAc). The desired product was obtained as acolorless oil (1.70 g, 8.33 mmol, 55.5% yield).
References:
JP5714745,2015,B2 Location in patent:Paragraph 0715; 0717
1198105-01-9
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202865-62-1
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94569-84-3
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