2-broMo-6-Methoxy-4-nitrobenzenaMine synthesis

Yield:16618-66-9 89%

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 15 - 30; for 2 h;

Steps:

34.1 Step 1

N-bromosuccinimide (1.96 g, 11.0 mmol)Add to 2-methoxy-4-nitroaniline (1.68 g, 10.0 mmol)In a solution of acetonitrile (20 mL),The reaction system was stirred at room temperature for two hours.The reaction was then diluted with ethyl acetate.Organic phase in turn,Washed with saturated saline,And dried with anhydrous sodium sulfate,filter,concentrate,The residue is dissolved in a methanol solution under reflux,Add water to precipitate a solid, and then cool to 0 ° C and stir for half an hour.filter,The filter cake was dried in vacuo to give compound 27.1 (2.2 g, yield: 89%) as a brown solid.

References:

CN108623615,2018,A Location in patent:Paragraph 0332; 0558; 0559; 0560