2-BROMO-6-NITROANILINE synthesis
- Product Name:2-BROMO-6-NITROANILINE
- CAS Number:59255-95-7
- Molecular formula:C6H5BrN2O2
- Molecular Weight:217.02
58534-94-4
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$10.00/1g
59255-95-7
136 suppliers
$28.00/1g
Yield:59255-95-7 91.3%
Reaction Conditions:
with ammonia in methanol at 100; for 16 h;Sealed tube;
Steps:
37
2-Bromo-6-nitroaniline A mixture of 1-bromo-2-fluoro-3-nitrobenzene (6.0 g, 27.27 mmol) and NH3 in CH3OH (7 M, 20 mL) was stirred in a sealed tube at 100 °C for 16 h. The solvent was removed and the residue was dissolved in H2O, and then extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel (ethyl acetate/petroleum ether = 1:100) to afford the product as a yellow solid (5.4 g, 91.3% yield).
References:
ARAXES PHARMA LLC;LI, Liansheng;FENG, Jun;WU, Tao;REN, Pingda;LIU, Yi;LIU, Yuan;LONG, Yun, Oliver WO2015/54572, 2015, A1 Location in patent:Page/Page column 271
245115-83-7
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$156.80/1g
59255-95-7
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615-36-1
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$10.00/5g
59255-95-7
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13296-94-1
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$6.00/1g
88-74-4
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59255-95-7
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$28.00/1g
875-51-4
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827-23-6
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$15.00/1g