ChemicalBook CAS DataBase List 2-Bromo-6-phenylpyridine

2-Bromo-6-phenylpyridine synthesis

13synthesis methods

Product Name:2-Bromo-6-phenylpyridine
CAS Number:39774-26-0
Molecular formula:C11H8BrN
Molecular Weight:234.09

626-05-1 Synthesis

626-05-1
497 suppliers
$9.00/10g

98-80-6 Synthesis

98-80-6
699 suppliers
$5.00/5g

39774-26-0
110 suppliers
$41.00/250mg

3558-69-8
105 suppliers
$68.00/5g

Yield: 80%

Reaction Conditions:

with (+/-)-7-(2,3-diacetoxypropyl)theophylline;palladium diacetate;lithium carbonate in water at 120; for 0.166667 h;Microwave irradiation;Green chemistry;Suzuki-Miyaura Coupling;

Steps:

Suzuki-Miyaura couplings were performed in glass tubes suitable for
General procedure: Suzuki-Miyaura couplings were performed in glass tubes suitable for microwave. Halopyridines (0.44 mmol), phenyl boronic acid (65.17 mg, 0.53 mmol), Li₂CO₃(63.7 mg, 0.89 mmol), 1 mol % of Pd(OAc)₂(1 mg, 4.45 ϰ 10^-3 mol), and 2 mol % of the corresponding ligand in 3 mL of distilled water. The mixtures were stirred and heated at 120 °C under microwave radiation during 10 min with a ramp of 1 min in a CEM Discover reactor coupled to a CEM Explorer robotic system. The resulting reaction mixture was cooled to room temperature and the mixture extracted with CH₂Cl₂ (3 ϰ 2 mL), the organic phase was treated with anhydrous Na₂SO₄ after filter over celite and analyzed by Gas Chromatography (GC-MS) on an Agilent 6890N GC with a 30.0 m DB-1MS capillary column coupled to an Agilent 5973 Inert Mass Selective detector. Additional experiments of catalysis were carried out under the same reaction conditions using different bases Na₂CO₃, K₂CO₃, Li₂CO₃, Cs₂CO₃, Rb₂CO₃, NaOH, KOH, Et₃N, and DIPEA.