ChemicalBook CAS DataBase List 2-BROMOCARBAZOLE

2-BROMOCARBAZOLE synthesis

12synthesis methods

Product Name:2-BROMOCARBAZOLE
CAS Number:3652-90-2
Molecular formula:C12H8BrN
Molecular Weight:246.1

35450-34-1
36 suppliers
$215.00/1g

3652-90-2
310 suppliers
$6.00/250mg

Yield:3652-90-2 75%

Reaction Conditions:

with triethyl phosphite in 1,2-dichloro-benzene at 80 - 150;Inert atmosphere;

Steps:

5 Preparation of 2-bromocarbazole
Under nitrogen protection, 200 mol of triethyl phosphite and 5 L of 1,2-dichlorobenzene were added to the reactor, and the temperature was raised to 150 ° C. and microcirculated.At about 80 ° C, 20 mol of 4'-bromo-2-nitrobiphenyl was dissolved in 18 L of 1,2-dichlorobenzene.Then, a solution of 4'-bromo-2-nitrobiphenyl in 1,2-dichlorobenzene was slowly added dropwise to a mixed system of triethyl phosphite and 1,2-dichlorobenzene under reflux.After the addition was completed, keep the reflux for 4 to 5 hours, detected to 4'-bromo-2-nitrobiphenyl reaction is completed.The ethyl acetate was recrystallized to give 2-bromocarbazole in a yield of 75%.

References:

Zhangjiagang Jiangsu University Of Science And Technology Industrial Technology Institute;Zhangjiagang Mi Xisi Optoelectric Materials Co., Ltd.;Cai Xingwei;Shao Yanliang;Zhao Yuyuan;Chen Fengshou;Lu Shengyu;Huang Cuiping CN105061296, 2018, B Location in patent:Paragraph 0033; 0034

FullText

70873-41-5 Synthesis